K Michael Gibson Selected Research

4-hydroxybutyric acid

12/2019	Temporal metabolomics in dried bloodspots suggests multipathway disruptions in aldh5a1-/- mice, a model of succinic semialdehyde dehydrogenase deficiency.
9/2019	Gamma-Hydroxybutyrate content in dried bloodspots facilitates newborn detection of succinic semialdehyde dehydrogenase deficiency.
1/2019	Age-related phenotype and biomarker changes in SSADH deficiency.
7/2013	Quantitation of gamma-hydroxybutyric acid in dried blood spots: feasibility assessment for newborn screening of succinic semialdehyde dehydrogenase (SSADH) deficiency.
5/2006	Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function.
11/2003	Monitoring of 4-hydroxybutyric acid levels in body fluids during vigabatrin treatment in succinic semialdehyde dehydrogenase deficiency.
8/2002	Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms.

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K Michael Gibson Research Topics

Disease

54	succinic semialdehyde dehydrogenase deficiency 01/2022 - 07/2002
14	Seizures (Absence Seizure) 01/2019 - 01/2003
7	Maple Syrup Urine Disease 01/2021 - 07/2009
6	Ataxia (Dyssynergia) 01/2019 - 12/2005
6	Epilepsy (Aura) 01/2017 - 12/2005
5	Gamma aminobutyric acid transaminase deficiency 05/2017 - 03/2004
5	Body Weight (Weight, Body) 12/2016 - 07/2009
4	Phenylketonurias (Phenylketonuria) 01/2021 - 01/2013
4	Status Epilepticus (Complex Partial Status Epilepticus) 11/2016 - 01/2006
3	Smith-Lemli-Opitz Syndrome 01/2021 - 09/2004
3	2-Hydroxyglutaricaciduria 01/2019 - 03/2010
3	Mevalonate Kinase Deficiency 03/2013 - 02/2003
3	Intellectual Disability (Idiocy) 05/2006 - 09/2004
3	Narcolepsy 03/2006 - 01/2004
2	Gliosis 11/2021 - 11/2020
2	Toxic Optic Neuropathy 10/2020 - 01/2017
2	Muscle Hypotonia (Hypotonia) 01/2019 - 04/2010
2	Edema (Dropsy) 01/2016 - 06/2011
2	Thrombosis (Thrombus) 01/2016 - 05/2011
2	Ischemia 01/2016 - 09/2010
2	Metabolic Diseases (Metabolic Disease) 03/2014 - 03/2013
2	Liver Diseases (Liver Disease) 03/2014 - 06/2013
2	2-Methylbutyryl-CoA Dehydrogenase Deficiency 01/2012 - 02/2006
2	Reperfusion Injury 06/2011 - 05/2011
2	Alcoholism (Alcohol Abuse) 03/2006 - 01/2004
2	Homocarnosinosis 01/2006 - 04/2004
2	Pyridoxine-dependent epilepsy 04/2004 - 03/2004
1	Multiple Sclerosis 01/2022
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022
1	Disease Progression 01/2022
1	Demyelinating Diseases (Demyelinating Disease) 01/2022
1	Dysbiosis 01/2022
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 01/2021
1	Rett Syndrome (Rett's Disorder) 01/2019
1	Neoplasms (Cancer) 11/2018
1	Cardiotoxicity 11/2018
1	Inflammation (Inflammations) 01/2017
1	Nervous System Diseases (Neurological Disorders) 12/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 10/2015

Drug/Important Bio-Agent (IBA)

43	gamma-Aminobutyric Acid (GABA)IBA 01/2022 - 08/2002
33	Succinate-Semialdehyde Dehydrogenase (Succinic Semialdehyde Dehydrogenase)IBA 11/2020 - 07/2002
9	Aminobutyrates (Aminobutyric Acid)IBA 01/2022 - 12/2010
9	EnzymesIBA 01/2021 - 01/2003
8	AcidsIBA 01/2020 - 01/2003
7	4-hydroxybutyric acidIBA 12/2019 - 08/2002
7	Neurotransmitter Agents (Neurotransmitter)IBA 09/2014 - 01/2003
5	Amino Acids FDA Link 05/2020 - 01/2013
4	CholesterolIBA 01/2021 - 02/2003
4	Biomarkers (Surrogate Marker)IBA 01/2020 - 07/2015
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 01/2010
3	Glutamine (L-Glutamine)FDA Link 11/2020 - 10/2003
3	Aldehyde DehydrogenaseIBA 01/2020 - 11/2016
3	Sodium Oxybate (gamma Hydroxybutyrate)FDA Link 09/2019 - 01/2003
3	Vigabatrin FDA Link 01/2017 - 07/2002
3	Taurine FDA Link 01/2016 - 07/2002
3	Branched-Chain Amino AcidsIBA 05/2014 - 07/2009
2	(3-aminopropyl)(n-butyl)phosphinic acidIBA 11/2021 - 05/2005
2	CreatineIBA 01/2021 - 05/2020
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2021 - 12/2010
2	Glutamic Acid (Glutamate)FDA Link 12/2019 - 10/2003
2	Butyric Acid (Butanoic Acid)IBA 01/2019 - 11/2014
2	alpha-hydroxyglutarateIBA 01/2019 - 03/2010
2	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 07/2009
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2018 - 01/2017
2	Sirolimus (Rapamycin)FDA Link 01/2017 - 11/2016
2	NCS 382IBA 12/2016 - 07/2002
2	Free RadicalsIBA 01/2016 - 05/2011
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 10/2015 - 12/2005
2	Dopamine (Intropin)FDA LinkGeneric 09/2014 - 10/2003
2	Proteins (Proteins, Gene)FDA Link 05/2014 - 01/2013
2	Carbolines (Beta-Carbolines)IBA 06/2011 - 05/2011
1	FarnesolIBA 01/2022
1	Corn Oil (Oil, Corn)IBA 01/2022
1	Ribosomal DNA (rDNA)IBA 01/2022
1	GABA-B Receptor AntagonistsIBA 11/2021
1	LipidsIBA 11/2021
1	acylcarnitineIBA 01/2021
1	glycocyamineIBA 01/2021
1	MethyltransferasesIBA 01/2021
1	Retinaldehyde (Retinal)IBA 10/2020
1	Volatile Fatty AcidsIBA 12/2019
1	Pharmaceutical PreparationsIBA 11/2018
1	Fluorouracil (Carac)FDA LinkGeneric 11/2018
1	Indole AlkaloidsIBA 11/2018
1	Superoxides (Superoxide)IBA 01/2017
1	Dietary ProteinsIBA 01/2017
1	Ion Channels (Ion Channel)IBA 01/2017
1	MTOR InhibitorsIBA 01/2017
1	Adenosine Triphosphate (ATP)IBA 01/2017
1	Oxidants (Oxidizing Agents)IBA 11/2016
1	CurcuminIBA 01/2016
1	NeopterinIBA 10/2015
1	Tyrosine (L-Tyrosine)FDA Link 09/2014

Therapy/Procedure

6	Therapeutics 11/2021 - 01/2013
5	Transplantation 03/2014 - 07/2009
2	Ketogenic Diet 08/2008 - 04/2008
1	Diet Therapy (Therapy, Diet) 01/2021
1	Drug Therapy (Chemotherapy) 11/2018
1	Intraperitoneal Injections 12/2016
1	Transcranial Magnetic Stimulation 01/2016